Clothianidin is an organic compound with the molecular formula C6H8ClN5O2S. Thiamethoxam is a new type of insecticide in the neonicotinoid class, which is highly efficient, safe, and selective. Its effect is similar to that of nicotinic acetylcholine receptors, and it has contact killing, gastric toxicity, and systemic activity. It is mainly used as an insecticide on rice, vegetables, fruit trees, and other crops to control pests such as aphids, leafhoppers, thrips, planthoppers, and other insects in the order Hemiptera, Coleoptera, Diptera, and certain Lepidoptera. It has the advantages of high efficiency, broad spectrum, low dosage, low toxicity, long efficacy, no harm to crops, safe use, and no cross resistance with conventional pesticides. It has excellent systemic and penetrative effects and is another variety to replace highly toxic organophosphorus pesticides. Its structure is novel, unique, and its performance is superior to traditional nicotine insecticides, making it a potential large-scale insecticide variety worldwide.

Chemical formula: C₆H₈ClN₅O₂S 

Molecular weight: 249.7

CAS login number: 210880-92-5

Melting point: 176.8 ℃

Appearance: Crystalline solid powder

Application: Insecticide

Material information

CAS NO. 210880-92-5; 205510-53-8

Chemical name: (E) -1- (2-chloro-1,3-thiazol-5-ylmethyl) -3-methyl-2-2-nitroguanidine

Structural formula: Physical and chemical properties: The appearance of the raw material is a crystalline solid powder, odorless, with a melting point of 176.8 ℃.

Vapor pressure: 1.3 × 10Pa (25 ℃).

Solubility: 0.327g/L for water, 15.2 g/L for acetone, 6.26g/L for methanol, 2.03 g/L for ethyl acetate, 1.32 g/L for dichloromethane, 0.0128 g/L for xylene,<0.00104 g/L for n-heptane, 0.938 g/L for n-octanol (measured at 25 ℃ for water and 20 ℃ for organic solvents).

Toxicity: Acute oral LD50>5000mg/kg (female/male) Acute dermal LD50>2000mg/kg (male/female)

Synthetic method

The synthesis methods reported domestically and internationally mainly include:

(1) 2-chloro-5-chloromethyl-1,3-thiazole reacts with N-methyl-N-nitro-S-methylisothiocyanate;

(2) 2-chloro-5-chloromethyl-1,3-thiazole reacts with N-methyl-N-nitrourea;

(3) 2-chloro-5-chloromethyl-1,3-thiazole reacts with N-nitro-S-methylisothiocyanine. Obtain 1- (2-chloro-thiazolomethyl) - N-nitro-S-methylisothiocyanate, and then methylamine to obtain the product;

(4) The product was prepared by decomposing 1- (2-chlorothiazole-5-methyl) -2-nitroimino-3,5-dimethyl-hexahydro-1,3,5-triazine.