[Name of Veterinary Drug]

English name: Tiamulin Fumarate Premix

Chinese Pinyin: Yanhusuosuan  Taimiaojunsu Yuhunji

【 Main Ingredients 】 Corydalis yanhusuo acid and tetracycline.

【 Appearance 】 This product is white granules.

Pharmacological effects: Pharmacodynamic Taimiao fungicide belongs to the Truncated Pleurotus ostreatus class of antibiotics, which has bactericidal effects on sensitive bacteria at high concentrations. Inhibit bacterial protein synthesis by binding to the 50S subunit of ribosomes. Taimiao fungicide has good antibacterial activity against Mycoplasma and Porcine Shigella, as well as against most Gram positive bacteria, including Staphylococcus and Streptococcus (excluding Group D Streptococcus). It has a certain effect on Actinobacillus pleuropneumoniae and weak antibacterial activity against most Gram negative bacteria. This product, when combined with streptomycin in a ratio of 1:4, can treat bacterial enteritis, bacterial pneumonia, and porcine dysentery caused by spirochetes. It has significant therapeutic effects on pneumonia caused by mixed infections of Mycoplasma pneumoniae, Bordetella bronchiseptica, and Pasteurella multocida.

The pharmacokinetics showed good absorption after oral administration in pigs. After a single dose administration, the bioavailability is about 85%, and the peak blood drug concentration is reached within 2-4 hours. The drugs entering the body are widely distributed, with the highest concentration in lung tissue. Teramycin is widely metabolized in the body, producing over 20 metabolites, some of which have antibacterial activity. The metabolites of tetracycline are mainly excreted from feces through bile, with about 30% excreted from urine.

【 Drug Interactions 】 (1) When used together with polyether antibiotics such as monensin, salinomycin, and methylsalinomycin, it can affect the metabolism of these polyether antibiotics, leading to slow growth, motor disorders, paralysis, and even death. (2) Co administration with other antibiotics that can bind to the 50S subunit of bacterial ribosomes, such as macrolide antibiotics and lincomycin, may lead to reduced efficacy due to competition for the same site of action.

【Function and Use】 Truncated Pleurotus ostreatus antibiotics. Mainly used for the prevention and treatment of Mycoplasma pneumoniae pneumonia and Actinobacillus pleuropneumoniae pneumonia in pigs, as well as for swine dysentery caused by Streptococcus pneumoniae.

【 Usage and Dosage 】 Calculate based on this product. Mixed feeding: 50-125g per 1000kg of feed for pigs, used continuously for 5-10 days.

【 Precautions 】 (1) It is prohibited to use it in combination with polyether antibiotics such as monensin, salinomycin, and methylsalinomycin. (2) Users should avoid drug contact with eyes and skin.

【Adverse reactions] When used at the recommended dosage, pigs may sometimes experience skin erythema. Excessive use can cause transient salivation, vomiting, and central nervous system suppression in pigs.

【 Rest period】 7 days for pigs

【 Packaging 】 500g/drum

[Specification] 80%