[Name of Veterinary Drug]
English name: Compound Sulfachlorpyridazine Sodium Powder

Chinese Pinyin: Fufang Huang'an L ü daqinna Fen

[Main ingredients] Sodium sulfamethoxazole, trimethoprim

【 Appearance 】 This product is a light yellow powder.

Pharmacological effects: This product has strong inhibitory effects on most Gram positive and Gram negative bacteria. Bacteria sensitive to sulfonamide drugs cannot utilize folate in the surrounding environment, and can only use para aminobenzoic acid and dihydropteridine to synthesize tetrahydrofolate under the action of bacterial dihydrofolate synthase. Activated tetrahydrofolate plays an important role in the transfer of one carbon groups in the synthesis of purine and thymidine. Sulfonamide drugs are structurally similar to para aminobenzoic acid and can compete with para aminobenzoic acid for dihydrofolate synthase in bacteria, hindering the synthesis of dihydrofolate and ultimately affecting nucleic acid synthesis, inhibiting bacterial growth and reproduction. The action of sulfonamide drugs can be antagonized by drugs that can metabolize into para aminobenzoic acid, such as procaine and butazone. In addition, pus and tissue breakdown products can also provide essential substances for bacterial growth, which can have an antagonistic effect on sulfonamide drugs. Trimethoprim is an antibacterial enhancer that can inhibit the activity of dihydrofolate reductase. The combination of the two can produce a synergistic effect and enhance the antibacterial effect.

[Drug Interactions] ① Some drugs containing para aminobenzoyl groups, such as procaine and tetracaine, can generate para aminobenzoic acid in the body. Yeast tablets contain para aminobenzoic acid, which is necessary for bacterial metabolism and can reduce the effect of the drug. Therefore, they should not be used together. ② When used together with diuretics such as thiazide or furosemide, it can exacerbate nephrotoxicity Sulfonamide drugs can usually replace drugs with high protein binding rates, such as methotrexate, prednisone, thiazide diuretics, salicylates, probenecid, and phenytoin. Although the clinical significance of these interactions is not fully understood, the enhancing effect of the replaced drugs must be monitored The combination of antacids and sulfonamides can reduce their bioavailability.

[Function and Use] Sulfonamide antibiotics. Used for the infection of Escherichia coli and Pasteurella in livestock and poultry.

[Usage and Dosage] Calculate based on this product. Oral administration: One day dose, 32mg per 1kg body weight for pigs and chickens; Pigs, use continuously for 5-10 days; Chicken, use continuously for 3-6 days.

Adverse reactions mainly manifest as acute reactions such as allergic reactions, while chronic reactions include granulocytopenia, thrombocytopenia, liver damage, kidney damage, and central nervous system reactions. Easy to deposit in urine, especially when taking high doses for a long time.

【 Precautions 】 ① Chickens that lay eggs for human consumption should not be used during the egg laying period. ② It shall not be used as a feed additive for a long time Crystals are prone to precipitate in the urinary tract, and the affected animal should be given plenty of water. It is advisable to administer an equal amount of sodium bicarbonate simultaneously during high-dose and long-term use When renal function is impaired, excretion is slow and should be used with caution It can cause dysbiosis of the gut microbiota, and long-term medication can reduce the synthesis and absorption of B vitamins and vitamin K. It is recommended to supplement with corresponding vitamins.

⑥ Cannot be used for patients with a history of allergies to sulfonamide drugs.

[Rest period] Pigs for 4 days, chickens for 2 days.

[Specification] 1000g: Sodium sulfamethoxazole 625g+Trimethylbenzylidene 125g

【 Packaging 】 500g/bag

[Storage] Store in a dark and sealed environment.