[Name of Veterinary Drug]
English name: Florfenicol Injection

Chinese Pinyin: Fubennikao Zhusheye

[Main ingredient] Fluphenicol

[Appearance] This product is a colorless to slightly yellow clear liquid.

[Pharmacological Effects] Pharmacodynamic Fluphenicol belongs to the class of broad-spectrum amide antibiotics, which are antibacterial agents. It exerts its effects by binding to the 50S subunit of ribosomes to inhibit bacterial protein synthesis. Has strong antibacterial activity against various Gram positive and Gram negative bacteria. Hemolytic Pasteurella, Pasteurella multocida, and Actinobacillus pleuropneumoniae are highly sensitive to florfenicol. In vitro, the antibacterial activity of florfenicol against many microorganisms is similar or stronger than that of methicillin. Some bacteria that are resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be sensitive to florfenicol.

Mainly used for bacterial diseases caused by sensitive bacteria in pigs, chickens, and fish, such as respiratory system diseases in cattle and pigs caused by hemolytic Pasteurella, Pasteurella multocida, and Actinobacillus pleuropneumoniae. Salmonella induced typhoid and paratyphoid fever, chicken cholera, chicken dysentery, Escherichia coli disease, etc; Bacterial sepsis, enteritis, and red skin disease in fish caused by Pasteurella, Vibrio, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacteriaceae.

Pharmacokinetic Fluphenicol is rapidly absorbed by oral administration, and the therapeutic concentration can be reached in the blood after about 1 hour. The peak blood drug concentration can be reached within 1-3 hours. The bioavailability is over 80%. Flufenicol is widely distributed in animals and can penetrate the blood-brain barrier. Mainly excreted in its original form from urine, with a small amount excreted with feces.

[Drug Interactions] (1) Macrolides and lincolamines have the same target of action as this product, which is to bind to the 50S subunit of bacterial ribosomes. When used together, they can produce antagonistic effects.

(2) It may antagonize the bactericidal activity of penicillin or aminoglycoside drugs, but it has not been proven in animals yet.

[Function and Use] Amide alcohol antibiotics. Used for infections caused by Bacillus subtilis and Escherichia coli.

[Usage and Dosage] Intramuscular injection: One dose, 0.067ml per 1kg body weight for chickens and 0.05-0.067ml for pigs, once every 48 hours, twice in a row. Fish 0.0017-0.0034ml, once a day.

[Adverse reactions] This product has a certain immunosuppressive effect when used at doses higher than the recommended level.

[Precautions] (1) Chickens that lay eggs for human consumption should not be used during the egg laying period. (2) Chickens should be used with caution. Embryotoxic, use with caution in livestock during pregnancy and lactation. (3) Animals during the vaccination period or with severe immune dysfunction are prohibited from use. (4) Animals with renal insufficiency require appropriate reduction or extension of dosing intervals.

[Rest period] Pigs 14 days, chickens 28 days, fish 375 days.

[Specification] 100ml: 30g

[Packaging] 100ml/bottle

[Storage] Sealed storage.